Chapter 8 The lymphorecticular system and bone marrow/Fig 8.40.jpg

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Cytogenetic abnormality in chronic myelogenous leukaemia (CML). This diagram depicts the classical t(9;22)(q34;q11) translocation associated with CML. This was the first cytogenetic abnormality ever detected in a human malignancy. There is a reciprocal translocation between the long arms of Ch 9 and Ch 22 bringing together the abl and bcr genes in the derivative Ch 22 (the Philadelphia chromosome).