Chapter 8 The lymphorecticular system and bone marrow/Fig 8.38.jpg

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Trephine biopsy of bone marrow in acute lymphoblastic leukaemia. (A) The marrow cellularity is almost 100% and is replaced by an infiltrate of small blast cells. (B) Nuclear positivity for terminal deoxynucleotidyl transferase (TdT) is identified in the majority of cells by immunocytochemistry.