Chapter 8 The lymphorecticular system and bone marrow/Fig 8.18.jpg

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Fluorescence in-situ hybridization (FISH) for the t(11;14) translocation is performed on a 1 µm paraffin section from the biopsy. Red and green signals indicate the 11 and 14 chromosomes, respectively. In a cell containing a t(11;14) reciprocal translocation (arrowed), one red and one green signal (corresponding to the normal chromosomes) and two fusion signals (where the red and green probes are brought together bythe translocation giving rise to emission of yellow light) are seen.