Chapter 8 The lymphorecticular system and bone marrow/Fig 8.15.jpg

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(A) Low-power view of the lymph node biopsy: the node is replaced by numerous follicular structures. At high power (B), there is a mixture of germinal centre-type cells comprising large cells (centroblasts) and smaller cells with a cleaved nucleus (centrocytes). Tingible body macrophages are absent. This pattern is characteristic of follicular lymphoma. The number of large cells is less than 5 per high-power field and therefore the lesion is regarded as grade 1.