Chapter 8 The lymphorecticular system and bone marrow/Fig 8.14.jpg

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Immunostaining for bcl2. (A) Reactive follicle: the germinal centre (GC) cells are negative. A small number of intrafollicular T-cells are positive. (B) In contrast, the GC cells in the neoplastic follicle in follicular lymphoma are strongly positive. Overexpression is a consequence of the t(14;18) translocation where the promoters on the IgH gene on chromosome 14 cause transcription of the bcl2 gene on chromosome 18 and is a useful tool to distinguish between reactive and malignant follicular lesions.