Chapter 4 Cell injury, inflammation and repair/Fig 4.27.jpg

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Principal steps in biosynthesis of interstitial collagens: (A) 1, Synthesis of pro-α chains in rough endoplasmic reticulum; 2, aggregation of three pro-α chains; 3, hydroxylation of lysine and proline residues; 4, secretion of procollagen molecule; 5, cleavage of propeptides; 6, alignment of collagen molecules to form fibrils; 7, aggregation of fibrils to form collagen fibre, seen here in longitudinal section and showing regular crossbanding (B). N = nucleus; ER = endoplasmic reticulum.