Chapter 4 Cell injury, inflammation and repair/Fig 4.25.jpg

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Hageman-factor-dependent pathways. Activation of Hageman factor (coagulation factor XII) by contact with collagen results in the acquisition of protease activity which is able enzymatically to activate the coagulation system, the fibrinolytic system and the kallikrein–kinin system. Kallikrein, an enzyme which converts kininogen to kinin, also amplifies the system by activating for Hageman factor. Kininases I and II inactivate kinins rapidly.