Chapter 15 The breasts/Fig 15.13.jpg

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Paget’s disease of the nipple. When DCIS extends along major ducts as far as the nipple, groups of carcinoma cells may enter the deeper layer of the epidermis and spread within it through the nipple and areola in the form of Paget’s disease of the nipple. In this case, atypical malignant cells with abundant cytoplasm and large nuclei are seen in the basal layers of the nipple.