Chapter 15 The breasts/Fig 15.12.jpg

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High-grade ductal carcinoma in situ (DCIS). Duct spaces are completely filled by a solid neoplastic proliferation of large, highly malignant cells. In this case the DCIS extends into the lobules as ‘cancerization’ of lobules; this may mimic invasion, but the process in both ducts and lobules has a surrounding myoepithelium (not shown). The DCIS within ducts bears central comedo-type necrosis.