Chapter 13 The kidneys and urinary tract/Fig 13.14.jpg

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(A) In diffuse proliferative glomerulonephritis there is marked hypercellularity often with an influx of neutrophil polymorphs and obliteration of the capillary spaces. The glomerular capillary walls are difficult to identify within this hypercellular glomerulus. (B) Immunofluorescence in these instances reveals the granular deposition of immune complexes in the capillary walls. (C) The electron microscopic findings in diffuse proliferative glomerulonephritis are
highly characteristic. In the subepithelial space there are large ‘hump’-shaped electron dense deposits.