Chapter 13 The kidneys and urinary tract/Fig 13.11.jpg

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(A) Membranous nephropathy is characterized by thickening of the glomerular capillary walls but with normal cellularity. The thickened capillary walls exhibit a spiky appearance on silver stained preparations. (B) Immunofluorescence staining reveals the presence of immune complexes, in this case IgM, within the capillary walls as granular deposits. (C) Electron microscopic examination reveals the presence of subepithelial electron dense immune complexes.