Chapter 12 The locomotor system/Fig 12.44.jpg

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(A) Karyotype showing a reciprocal translocation between chromosomes 11 and 22 as seen in Ewing’s Sarcoma. (B) Chromosome ideograms showing the t(11;22) translocation with chromosome 11 in black and 22 in blue. The red and green regions represent the EWSR1 break apart probe (Vysis) for the Ewing’s gene. (C) Diagram showing interphase FISH pattern with the split signal indicating a translocation involving the Ewing’s gene. (D) Interphase FISH image showing the pattern illustrated in C.