Chapter 12 The locomotor system/Fig 12.42.jpg

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Alveolar rhabdomyosarcoma. The tumour is composed of sheets of round cells which show central discohesion with the formation of an alveolar or honeycomb pattern. Insert (lower left) shows that the nuclei stain with an antibody directed against myogenin, a nuclear regulatory protein involved in skeletal muscle differentiation, helping to confirm the diagnosis.