Chapter 11 The nervous systems and the eye/Fig 11.47.jpg

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Glioblastoma. (A) There is a partly cystic necrotic tumour in the posterior frontal lobe that has remarkably well-defined margins. Associated brain swelling has produced internal herniation, ventricular asymmetry and a shift of the medial structures. (B) There are serpiginous foci of necrosis with surrounding nuclear pseudopalizading. The tumour is pleomorphic and multinucleate tumour giant cells, vascular endothelial cell hyperplasia and mitotic figures are present.