Chapter 1 Applications of pathology /Fig 1.05.jpg

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Interphase fluorescence in-situ hybridization (FISH) on a lymphoma using the IGH/CCND1 dual fusion probe (Vysis). (A) Normal pattern showing two green signals representing IGH on chromosome 14 and two red signals representing CCND1 on chromosome 11. (B) Abnormal pattern in a mantle cell lymphoma showing a single green IGH signal, a single red CCND1 signal and two fused signals representing the two derived chromosomes involved in the t(11;14) translocation. (For more information on the probe used see www.vysis.com/AnalyticSpecificReagents(ASR)_59424.asp
(Part # 32-191017.)